The link between Chronic Traumatic Encephalopathy (CTE) and repeated subconcussive head trauma (as in football) has been well documented. What is less well understood is the pathophysiologic mechanism by which this process occurs over time. This paper suggests that a disruption in the blood brain barrier (BBB) occuring after sub-concussive head trauma can elicit an auto-immune response, whereby auto-antibody production and infiltration of the brain could potentially lead to the long term cognitive damage as seen in CTE.
This is only the beginning. Science lurches toward the truth. And Pop Warner leagues can flip that hourglass over any minute now. The end of football as we know it is coming, and quickly.